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Franchisee (Unable to retrieve license). All rights reserved.Tissue-specific oxidation of phytanic acid in B6C3F1 mice fed normal or 1% phytanic acid diets.
Phytanic acid (PTA) is a branched-chain saturated fatty acid that accumulates in tissues of patients with Refsum's disease, a fatty acid oxidation disorder caused by deficiency of phytanoyl-CoA hydroxylase. The capacity of the major rat and human mitochondrial fatty acid beta-oxidase (FAO) to utilize PTA as a substrate is controversial. We have examined PTA metabolism in control and PTA-fed mice in order to determine whether mouse FAO contributes to the catabolism of this compound. The use of radiolabeled PTA in feeding experiments indicated that control mice oxidized (beta-oxidized) PTA to CO2 at a rate of 1.8 nmol/h/g liver. However, the rate was lower in mice fed 1% PTA in the diet (0.37 nmol/h/g liver). In contrast, mice fed 0.3% PTA oxidized PTA to CO2 at a rate of 2.1 nmol/h/g liver. Our studies indicate that mouse FAO is a significant contributor to PTA oxidation.This week was a hectic one and we had some pretty serious changes in the city council. By far the most important one for us was that the Houston City Council voted to keep the logo for the Houston Equal Rights Ordinance (HERO) unchanged. HERO, the ordinance protecting LGBT Houstonians, was passed earlier this month after a public battle between advocates and detractors.
We at the Center for Equal Opportunity are a strong opponent of HERO and our position hasn’t changed. Like our opponents, we think it should be repealed because it is unconstitutional ac619d1d87
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